How to use biorphen

Biorphen is a ready-to-use formulation of phenylephrine, so there’s no need for dilution or compounding.1

Administering Biorphen

Biorphen can be quickly, conveniently administered without compounding from concentrate.1
  • Bolus intravenous injection: 40 mcg to 100 mcg every 1-2 minutes as needed, not to exceed 200 mcg
  • 5 mL ampule is for single use only

ONE STANDARD RTU FORMULATION
THROUGHOUT YOUR HOSPITAL

Stock in the OR, ED, ICU, ASC, and on crash carts

3-year shelf life2 means less frequent restocking

Incorporate into hospital emergency protocols.

Can be administered by any trained staff without compounding

Aligns with standardization recommendations of patient safety and professional organizations: ISMP3, APSF4, ASHP5.

Biorphen is Clinically Effective1

  • The onset of blood pressure increase following an intravenous bolus phenylephrine hydrochloride administration is rapid, typically within minutes1
  • Phenylephrine is recommended as a first-line vasopressor during cesarean section under spinal anesthesia due to extensive supporting data6*
  • Phenylephrine is an acceptable vasopressor for septic shock in the case of norepinephrine-associated arrhythmias or in salvage therapy7**

*α-agonist drugs are the most appropriate agents to treat or prevent hypotension following spinal anaesthesia. Although those with a small amount of β-agonist activity may have the best profile, phenylephrine is recommended due to
the amount of supporting data.6

**Phenylephrine is not recommended in the treatment of septic shock except in circumstances where (a) norepinephrine is associated with serious arrhythmias, (b) cardiac output is known to be high and blood pressure persistently low or (c) as salvage therapy when combined inotrope/vasopressor drugs and low-dose vasopressin have failed to achieve MAP target (grade 1C).7

Did you know? Push-Dose Pressors in the Emergency Department

Bolus administration of phenylephrine, or “push-dose pressors,” are reportedly widely used in the Emergency Department (ED) for transient hypotension, or until central access can be obtained to initiate a continuous infusion of vasopressors8-10. Authors note that phenylephrine in the ED is usually manually compounded “on demand” at the patient’s bedside for immediate use.9, 10

Biorphen can be quickly, conveniently administered without compounding or dilution.1

Interested in supplying Biorphen for your hospital?

References:

  1. Biorphen [Package Insert]. Deer Park, IL: Eton Pharmaceuticals Inc; 2019.
  2. Biorphen data on file. Deer Park, IL: Eton Pharmaceuticals Inc; 2019.
  3. 2018-2019 Targeted Medication Safety Best Practices for Hospitals. Institute for Safe Medication Practices (ISMP). https://www.ismp.org/guidelines/best-practices-hospitals. Accessed November 19, 2019.
  4. Recommendations for improving medication safety. Consensus from four work groups at the 2018 APSF Stoelting Conference on Medication Safety. Anesthesia Patient Safety Foundation. https://www.apsf.org/medication-safety-recommendations/. Accessed November 19, 2019.
  5. American Society of Health-System Pharmacists. ASHP guidelines on preventing medication errors in hospitals. Am J Health-Syst Pharm. 2018;75:1493–1517.
  6. Kinsella SM, Caravallo B, Dyer RA, et al. International consensus statement on the management of hypotension with vasopressors during Caesarean section under spinal anesthesia [published online ahead of print November 1, 2017]. Anaesthesia. 2018;73(1):71-92. doi: 10.1111/anae.14080.
  7. Dellinger RP, Levy MM, Rhodes A, et al; for Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165-228. dio: 10.1007/s00134-012-2769-8.
  8. Swenson K, Rankin S, Daconti L, Villarreal T, Langsjoen J, Braude D. Safety of bolus-dose phenylephrine for hypotensive emergency department patients [published online ahead of print February 19, 2018]. Am J Emerg Med. 2018;36(10):1802-1806. doi:10.1016/j.ajem.2018.01.095.
  9. Tilton LJ, Eginger, KH. Utility of push-dose vasopressors for temporary treatment of hypotension in the emergency department. J Emerg Nurs. 2016;42:279-281. doi:10.1016/j.jen.2016.03.007.
  10. Holden D, Ramich J, Timm E, Pauze D, Lesar T. Safety considerations and guidelines-based safe use recommendations for “bolus-dose” vasopressors in the emergency department. Ann Emerg Med. 2018;71(1):83-92. doi:10.1016/j.annemergmed.2017.04.021.