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IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS
None
WARNINGS AND PRECAUTIONS
Biorphen can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure. Can also cause excessive peripheral and visceral vasoconstriction, and ischemia to vital organs. Extravasation during intravenous administration can cause necrosis or sloughing of tissue. Can cause severe bradycardia and decreased cardiac output, and can increase the need for renal replacement therapy in patients with septic shock, increased pressor effect in patients with autonomic dysfunction, and increased pressor effect with concomitant oxytocic drugs.
Overdose of Biorphen can cause a rapid rise in blood pressure. Symptoms of overdose include headache, vomiting, hypertension, reflex bradycardia, a sensation of fullness in the head, tingling of the extremities, and cardiac arrhythmias including ventricular extrasystoles and ventricular tachycardia.
ADVERSE REACTIONS
DRUG INTERACTIONS
Indications and Usage
Biorphen® (phenylephrine hydrochloride) is indicated for patients with clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.
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